I have used CBD and a 1-1 mint that I have mircrodosed with, both can make me tired during the day. I was recommended this by HelloMD. I’m looking for something to give me a lift to finish tasks, not make me tired.


Hi there!
I can’t be sure why someone recommended that you try CBG in order to avoid feeling fatigued. CBG has been shown to prevent the re-uptake of GABA, which effectively increases the amount of GABA in the space between nerves called synapses, to exert its effects.  Activation of the GABA receptor is what elicits the anxiolytic and sedative effects after consuming alcohol, benzodiazepines or barbiturates. However, that does not necessarily mean that CBG would fatigue you. Due to variations of each individuals endocannabinoid system, the effects of cannabinoids are not exactly the same from one individual to the next, so I don’t see any harm in trying!

However, preclinical research does suggest that CBG may have a profound impact on how we treat several conditions with cannabis. Studies performed on animals have shown that CBG has anti-inflammatory, neuroprotective, anti-cancer, bone-building, appetite stimulating and anti-seizure properties. CBG has the potential to treat glaucoma, IBS, epilepsy, chronic pain, osteoporosis, Huntington’s disease, bladder dysfunction, just to name a few.
https://www.ncbi.nlm.nih.gov/pubmed/25269802

drkim


Although, I believe that one unique property of CBG provides the potential to revolutionize how we treat conditions with cannabis: It competitively binds to the CB1 receptor. Cannabis’ psychoactive effects occur when THC binds the CB1 receptor which is located most prominently in the central nervous system. Therefore, if we can block the CB1 receptor, a patient would be less limited by the psychoactive effects of THC, which would then allow the patient to consume more THC, and thus reap the medical benefits derived from additional THC binding to the other cannabinoid receptor, CB2—binding the CB2 receptor does not result in psychoactivity.

CB2 receptors are densely located throughout the immune system and related organs. The anti-inflammatory response to cannabis is mainly due to the biological response that occurs when THC binds the CB2 receptors found on immune cells. Therefore, CBG would allow for more THC which would lead to more pain relief.

Additionally, the anti-inflammatory properties of THC is what is most responsible for its neuroprotective properties, and thus CBG could help better treat conditions, such as Huntington’s disease, TBI, multiple sclerosis and Parkinson’s disease.  Even better, CBG has anti-inflammatory properties.

drkim


CB2 receptors are also densely found throughout the gastrointestinal system, where they modulate intestinal inflammatory response. This is mostly why sufferers of Crohn’s disease and IBS benefit from consuming cannabis. Even better, CBG also seems to reduce symptoms and the progression if IBS independent of THC.
https://www.ncbi.nlm.nih.gov/pubmed/23415610

Perhaps the most profound potential use of CBG, would be the treatment of cancer. CBG seems to have anti-tumor properties of its own. In a recent study, researchers found that CBG selectively inhibits the growth of colorectal cancer cells.
https://www.ncbi.nlm.nih.gov/pubmed/25269802
Furthermore, as already described, CBG would allow for the consumption of more THC, which has also has anti-tumor properties.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852356/
Further still, CBG helps alleviate nausea and stimulate the appetite without any psychoactivity.

Altogether, CBG has the potential to become a major weapon for the treatment of cancer and several other difficult to treat conditions.

I hope this helps!

drkim


test

BartSmart


Hi there!
I can’t be sure why someone recommended CBG for an energy boost. CBG has been shown to prevent the re-uptake of the nerve-calming neurotransmitter Gamma-Amino Butyric acid (GABA), which in effect increases the amount of GABA available to activate the GABA receptor; activation of the GABA receptor is what elicits the anxiolytic and sedative effects after consuming alcohol, benzodiazepines or barbiturates.

However, preclinical research does suggest that CBG may have a profound impact on how we treat several conditions with cannabis. Studies performed on animals have shown that CBG has anti-inflammatory, neuroprotective, anti-cancer, bone-building, appetite-stimulating and anti-seizure properties. CBG has the potential to treat conditions, such as IBS, epilepsy, chronic pain, cancers, osteoporosis, Huntington’s disease and multiple sclerosis, just to name a few.
https://www.ncbi.nlm.nih.gov/pubmed/25269802

drkim


Although, I believe that one unique property of CBG provides the potential to revolutionize how we treat conditions with cannabis: It competitively binds to the CB1 receptor. Cannabis’ psychoactive effects occur when THC binds the CB1 receptor which is located most prominently in the central nervous system. Therefore, if we can block the CB1 receptor, a patient would be less limited by the psychoactive effects of THC, which would then allow the patient to consume more THC, and thus reap the medicinal benefits derived from additional THC binding to the other cannabinoid receptor, CB2—binding the CB2 receptor does not result in psychoactivity.

CB2 receptors are densely located throughout the immune system and related organs. The anti-inflammatory response to cannabis is mainly due to the biological response that occurs when THC binds the CB2 receptors found on immune cells. Therefore, CBG would allow for more THC which would lead to more pain relief.

Additionally, the anti-inflammatory properties of THC is what is most responsible for its neuroprotective properties, and thus CBG could help better treat conditions, such as Huntington’s disease, TBI, multiple sclerosis and Parkinson’s disease.  Even better, CBG has anti-inflammatory properties independent of THC .

drkim


CB2 receptors are also densely found throughout the gastrointestinal tract, where they modulate intestinal inflammatory response. This is mostly why sufferers of Crohn’s disease and IBS benefit from consuming cannabis. Even better, CBG also seems to reduce symptoms and the progression if IBS independent of THC.
https://www.ncbi.nlm.nih.gov/pubmed/23415610

Perhaps the most profound potential use of CBG, would be for the treatment of cancer. CBG seems to have anti-tumor properties of its own. In a recent study, researchers found that CBG selectively inhibits the growth of colorectal cancer cells.
https://www.ncbi.nlm.nih.gov/pubmed/25269802
Furthermore, as already described, CBG would allow for the consumption of more THC—which possesses well documented anti-tumor properties.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852356/
Further still, CBG helps alleviate nausea and stimulate the appetite without any psychoactivity.

drkim

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