Clinical trials using cannabinoids for pain treatment demonstrate how cannabinoids induce analgesia via the endocannabinoid system. Studies show that combining THC and CBD may improve their therapeutic effects. Both cannabinoids work together synergistically and work better in combination with one another than they do on their own. They address the pain through their analgesic and anti-inflammatory properties. Clinical research has shown that a 1:1 CBD:THC ratio is most effective for pain. Numerous randomized clinical trials have demonstrated safety and efficacy for Sativex (a 1:1 THC:CBD medication) in central and peripheral neuropathic pain, rheumatoid arthritis and cancer pain.
Russo, E. B. (2008). Cannabinoids in the management of difficult to treat pain. Therapeutics and Clinical Risk Management, 4(1), 245259.