Cannabis affects the body differently depending on how it is consumed. For an edible to work, it has to first pass through the body’s primary detox organ, the liver. In the liver, THC is broken down into a smaller metabolite called 11-hydroxy-THC. The two major cannabinoids found in cannabis, tetrahydrocannabinol (THC) and cannabidiol (CBD) bind with or influence the cannabinoid receptors (CB1 and CB2) of the endocannabinoid system within the body. Previous studies had actually implicated action of CB1 in the progression of cirrhosis, fibrosis, and other liver diseases. However, CB2 receptor activation has shown beneficial effects on alcoholic fatty liver, hepatic inflammation, liver injury, regeneration and fibrosis and CBD has. Therefore, research suggests that using cannabis to selectively activate the CB2 receptor offers therapeutic potential for cirrhosis and other liver diseases (Mallat, et al., 2011).
Hi there! Did you mean edibles?
It depends. They aren’t necessarily bad for your liver, but if you have a liver disease two of our doctors recommend cannabis tinctures instead of edibles. You can check out both their answers here: https://www.hellomd.com/answers/5726b0fd543cfc0008000075/i-am-trying-to-understand-if-cannabis-can-be-bad-for-the-liver-and-if-the-method-of-ingestion-matters-to-the-liver
Hope that helps!