Research on and the urinary bladder revealed that the endocannabinoid-signaling is involved in the signal pathways regulating bladder relaxation. It was postulated that the binding of endocannabinoids to the cannabinoid receptors (CB1 and CB2) may result in relaxation of the urinary bladder. Dysregulation of the Endocannabinoid System in human bladder may be responsible for the aetiopathogenesis of Overactive Bladder Syndrome (OAB) and Detrusor Overactivity (DO).
Another study on Over active Bladder suggests that Cannabinoids appear to work at several levels centrally and peripherally on detrusor smooth muscle, suggesting that they might produce similar effects in patients with neurogenic and nonneurogenic Over active bladder. I would recommend starting at a 1:1 THC:CBD ratio 2.5-5mgs daily, while titrating upwards in milligrams as needed.