Hello. No, CBD will not cause depersonalization, to the contrary, it may be able to treat it. Depersonalization disorder is marked by periods of feeling disconnected or detached from one’s body and thoughts (depersonalization). The disorder is sometimes described as feeling like you are observing yourself from outside your body or like being in a dream. Drug-induced Depersonalization is extremely common with people who use weed, ketamine, LSD. Tetrahydrocannabinol aka THC is the culprit here since its psychoactive and may induce anxiety and psychosis. However, CBD is the ‘natural’ antidote to THC’s negative effects including its psychoactive effects. CBD induces feelings of calmness and peacefulness. There is evidence that "CBD has antipsychotic effects, as demonstrated by a study finding that CBD reduced drug-induced depersonalization in healthy volunteers. In a case report of a patient with schizophrenia who could not tolerate conventional antipsychotics, a significant reduction in psychotic symptoms was reported after administration of high-dose CBD for 4 weeks, with a return of symptoms after discontinuation."
Michael E. Schatman. Medical Marijuana: The State of the Science – Medscape – Feb 06, 2015.