My Daughter has Ulcerative Colitis. She is on Remicade but still has bleeding. I have heard about CBD oil. We live in New Jersey . How can I get information about purchase and dosage.
Answer - Doctor Marsha Bluto
Inflammatory bowel diseases such as Crohn’s and Ulcerative Colitis, are immune deficiency diseases that involves chronic inflammation of the gastrointestinal tract. They can cause persistent cramping, diarrhea, obstruction, and rectal bleeding.
Patients suffering from Crohn's disease, or from any type of irritable bowel disease, have a higher level of cannabinoid receptors in their gastrointestinal tract. The endocannabinoids found in cannabis can help to reduce the inflammation caused by these conditions. In 2013, the journal Clinical Gastroenterology and Hepatology found that 10 of 11 patients in the cannabis group of a study had a significant reduction in their symptoms and 5 had complete remission with the use of cannabis.
Our body has its own cannabinoid system referred to as the endocannabinoid system and we have cannabinoid receptors, CB1 and CB2, in the digestive system. The cannabinoid system has been shown to be involved in regulating the immune system through its immunomodulatory properties. Cannabinoids suppress inflammatory response and reduce disease symptoms. This happens through multiple, complicated biochemical pathways.
When CB1 receptors are activated, they can decrease intestinal movement and the secretion of intestinal fluids. CB2 receptor stimulation can lead to an increase in T-cell, white blood cells, and other body cells that mediate inflammation. There is also evidence that THC may be helpful in reducing the leakage of fluids through the lining of the gastrointestinal tract.
Remicade, or infliximab, is a monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, Crohn's disease, ankylosing spondylitis and plaque psoriasis of the skin. Remicade is often used when other medicines have not been effective. It blocks the action of a protein in your body called tumor necrosis factor-alpha (TNF-alpha) reducing inflammation and altering immune response. Common side effects of Remicade include headache, stomach pain, nausea, stuffy nose, sinus pain, skin rash, or flushing.
Due to stomach sensitivities in patients with Crohn’s, vaporization or smoking has seemed to be the best delivery method for medical cannabis. Edible forms, however, allow for the cannabis to directly sooth the gastrointestinal tract.
Inflammatory Bowel Disease is a qualifying condition in New Jersey for Medical Marijuana and your state has licensed dispensaries.
While I would recommend using CBD oil as an adjunct to current therapies, I have had good results for patients using CBD Oils in a 2:1 ratio several times per day with the addition of some THC pills in extracted form in capsules for flares and to stimulate appetite and sleep.